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Kosmos
Astronomia Astrofizyka
Inne

Kultura
Sztuka dawna i współczesna, muzea i kolekcje

Metoda
Metodologia nauk, Matematyka, Filozofia, Miary i wagi, Pomiary

Materia
Substancje, reakcje, energia
Fizyka, chemia i inżynieria materiałowa

Człowiek
Antropologia kulturowa Socjologia Psychologia Zdrowie i medycyna

Wizje
Przewidywania Kosmologia Religie Ideologia Polityka

Ziemia
Geologia, geofizyka, geochemia, środowisko przyrodnicze

Życie
Biologia, biologia molekularna i genetyka

Cyberprzestrzeń
Technologia cyberprzestrzeni, cyberkultura, media i komunikacja

Działalność
Wiadomości | Gospodarka, biznes, zarządzanie, ekonomia

Technologie
Budownictwo, energetyka, transport, wytwarzanie, technologie informacyjne

HEPATOTOXIC EFFECT OF ITRACONAZOLE IN EXPERIMENTAL RATS

Itraconazole is a widely used antifungal drug. In situations such as managing patients with gastrointestinal basidiobolomycosis, third of which cases world-wide occur in the southwestern region of Saudi Arabia, prolonged treatment with this drug is required. Thus, this is study was designed to investigate the hepatotoxicity of long term administration of itraconazolein in Wistar rats. Two groups of rats were treated with itraconazole at doses of 5 and 10 mg kg-1, for 30 and 60 days, respectively. At the end of each period sera of rats were tested for liver enzymes (including ALT, ALP and γGTT, albumin and protein). Animals were sacrificed and livers were processed for histological examination. Compared to controls, all rats treated for 30 and 60 days showed significant elevation in the levels of liver enzymes. Histologically there was severe liver injury. Although itraconazole is a safe antifungal drug, prolonged treatment with this drug may lead to severe hepatitis and liver cell injury. Patients who require treatment with this drug for long periods (12 to 18 months) should have their liver functions periodically monitored.