Hepatitis C virus infection, besides its substantial unfavorable
impact on liver health, has several other manifestations, from which we have
focused on its associations with insulin resistance and diabetes mellitus in
an in vitro setting in this review of the literature. Several epidemiologic
studies have already proven the strong association between chronic HCV infection
and development of diabetes mellitus. However, attempts to clarifying molecular
mechanisms for this association have not made up until recent years. We made
a comprehensive review of the literature but we only found 6 studies investigating
HCV impact on insulin signaling pathway in an in vitro era. We tried
to review and compare the findings of these studies to show what we already
know on the issue and what we still need to know.
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